BEGIN:VCALENDAR VERSION:2.0 PRODID:-//http://www.rotaryclubofnorthsydneysunrise.org.au///NONSGML kigkonsult.se iCalcreator 2.10.15// METHOD:PUBLISH BEGIN:VEVENT UID:20200301T160521UTC-0800eMDbUX@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION:Melanoma is a type of skin cancer affecting both adults and chi ldren\, and is the third most common cancer in Australia. Immunotherapy is a type of biological therapy that stimulates the body’s immune system to fight cancer cells.  Melanoma patients who have received Immunotherapy hav e an overall survival rate of 70%. Although the majority of melanoma patie nts responded to immunotherapy\, nearly 50% of patients developed drug res istance or experienced toxicities during treatment. \nAs melanoma tumours are diverse and composed of distinct genetic and phenotypic features\, the cells within the tumours are heterogenous. This heterogeneity of cells in cancer can be a major clinical problem because heterogeneity reduces the efficacy of drug resulting in failed treatment. Our recent work highlighte d not only the specific gene markers in cell populations that responded to specific immunotherapy drugs\, but also the heterogeneity of cellular gen e expression among the non-responding patients who failed treatment. \nNew single-cell sequencing analysis identified distinct response patterns tha t are associated with longer progression-free survival and greater tumour shrinkage in immunotherapy. Also\, the genetic expression and phenotypic p rofiles will facilitate rationally designed treatment strategies.\nCamelia will explain this leading-edge work and its significance in treating Mela noma and other cancers.\n \nCamelia is Postdoctoral Scientist at the Centr al Clinical School\, Melanoma Institute Australia.   Her research goal is to reshape the molecular determinants of treatment response\, resistance\, toxicity and survival in order to improve outcomes in patients. Her curre nt work involved Phase I\, II and III clinical trials in advanced metastat ic melanoma\, particularly focus on identifying molecular biomarker that c orrelates with response and resistance to cancer immunotherapy. DTSTART:20200406T210000Z DTEND:20200406T223000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:Immunotherapy END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0824PIdh7z@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION: \n \nno meeting - Pride of workmanship meeting previous day \n  \n \n\n\n  DTSTART:20200330T210000Z DTEND:20200330T223000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:no meeting - Pride of workmanship meeting previous day END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0832VUs12Z@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION:\n\n \n Combined Meeting with Rotary Club of Crows Nest\, Lane Cove and North Sydney \n \nThe Rotary Club of North Sydney Sunrise seeks t o recognize individuals and small businesses whose service\,\n \nperforman ce\, or workmanship has time and time again demonstrated their “Pride of W orkmanship”. \n \nAwards will be presented to:  TBA\n \n \n \nxxx\n \n \n  \n \n \n \n \n \n \n  DTSTART:20200330T083000Z DTEND:20200330T113000Z LOCATION:Northbridge Golf Club (Sailors Bay Road\, Northbridge) SUMMARY:Pride of Workmanship awards END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0842Nl9BwK@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION:\n\n \nThe Rotary Club of North Sydney Sunrise  \ninvites you & amp\; your partner to a relaxed social dinner  \nat  Piato \n \n Tuesday 2 4 March 2020   7:00 p.m. for 7:30 p.m.\n \n \n \n \n \n \n \n  DTSTART:20200324T090000Z DTEND:20200324T110000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:Social Dinner meeting END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0849kI8sfW@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION: \nClub Forum  \nWe will discuss our current program and causes we wish to support in the future. In doing so\, we shall bear in mind our Club goals established last year to distribute our support amongst Rotary projects and the community. Please bring along your ideas\, suggestions a nd proposals – the more the better! \nThe agenda will include \n\nFinances \nSecretarial \n\n\nFoundation \nClub Service \nPublic relations \nCommuni ty\nYouth      \nInternational\nVocational - Pride of Workmanship dinner   \n\n\nAny other general business\n\n \n Guests are always welcome.\n \n  \n \n\n\n  DTSTART:20200316T210000Z DTEND:20200316T223000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:Club Forum END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0861ctIVrR@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION:The Western Harbour Tunnel will deliver a new crossing of Sydne y Harbour and creates a western bypass of the Sydney CBD. The project incl udes upgrading four kilometres of one of Australia’s busiest roads\, the W arringah Freeway. This will address congestion\, improve safety and provid e more choice for how to move around Sydney.\n \nThis talk will explain\n \n·       The high level plan for the project including the environmental considerations\, and\n·        The status of the project\n\n \nTim Kwok is the Senior Community and Stakeholder Engagement Manager\, Transport for N SW.  He has over 15 years of experience in marketing and communications\, specialising in communications on major infrastructure projects such as We stConnex and Western Harbour Tunnel and Beaches Link. Tim has expertise in proactively identifying potential issues within the community and deliver ing effective solutions to mitigate them.\n \n \nMarcus Hall is a Communit y and Stakeholder Engagement Officer\, Transport for NSW.  He first entere d the public sector by participating in the NSW Government Graduate Progra m\, which involved placements at Roads and Maritime Services\, Transport f or NSW and the Department of Premier and Cabinet. He is passionate about t he role communications and community engagement play in promoting understa nding\, improving decision-making and delivering benefits for the people o f NSW.\n \n  DTSTART:20200309T210000Z DTEND:20200309T223000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:Western Harbour Tunnel and Warringah Freeway Upgrade END:VEVENT BEGIN:VEVENT UID:20200301T160521UTC-0879a6WkpE@http://www.rotaryclubofnorthsydneysunrise .org.au/ DTSTAMP:20200301T160521Z DESCRIPTION: This talk is about plastic waste. It will cover: \n\n·        the early history of plastic\, \n\n\n·        How the industry grew so big   \n\n \n\n·        where it is today\n\n \n\n·        Some facts about re cycling &\; \n\n \n\n·        information about an exciting way to mini mise littering.\n\n \nDon Wilson had a successful business career includin g running a hire company. Since the year 2000 Don has been involved in bus hcare in the Northbridge area. He was the founder of Bushcare’s Major Day Out. Starting with one site in Northbridge this initiative grew into a Nat ional event. In 2016\, 286 groups took part including groups from every st ate.  At 87 years old\, inspired by Craig Reucastle’s documentary\, Don st arted “Winning the War on Waste.” Later came “Get Fitter With Litter” & \; “Adopt a Street &\; Keep it Neat.”\n  DTSTART:20200302T210000Z DTEND:20200302T223000Z LOCATION:Piato Restaurant (123 Blues Point Road\, McMahons Point NSW 2060\, Australia) SUMMARY:Winning the War on Waste END:VEVENT END:VCALENDAR